Probiotic Lactobacillus Dose Required to Restore and Maintain a Normal Vaginal Flora
(2001) FEMS Immunol Med Microbiol. Dec;32(1):37-41. Reid G, Beuerman D, Heinemann C, Bruce AW.
Probiotic Lactobacillus dose required to restore and maintain a normal vaginal flora. 2001
Forty-two healthy women were randomized to receive one of three encapsulated Lactobacillus rhamnosus GR-1 plus Lactobacillus fermentum RC-14 probiotic dosage regimens or L. rhamnosus GG by mouth each day for 28 days. However, the vaginal flora, assessed by Nugent scoring, was only normal in 40% of the cases, and 14 patients had asymptomatic bacterial vaginosis. Treatment with L. rhamnosus GR-1/L. fermentum RC-14 once and twice daily correlated with a healthy vaginal flora in up to 90% of patients, and 7/11 patients with bacterial vaginosis converted to normal or intermediate scores within 1 month. Ingestion of L. rhamnosus GG failed to have an effect. This study confirms the potential efficacy of orally administered lactobacilli as a non-chemotherapeutic means to restore and maintain a normal urogenital flora, and shows that over 108 viable organisms per day is the required dose.