Effect of Vaginal Lubricants on Sperm Motility and Chromatin Integrity:

A Prospective Comparative Study.
Fertility & Sterility. 2008 Feb;89:375-379

This study found that percent sperm motility did not significantly differ between "controls and Pre-Seed, whereas FemGlide®, Replens®, and Astroglide® lubricants demonstrated a significant decrease in motility." There was also "no significant difference in percent DNA fragmentation index between the HTF controls and Pre-Seed, but a significant decline in sperm chromatin quality occurred with FemGlide® and K-Y Jelly®. Pre-Seed does not cause a significant decrease in progressive sperm motility or chromatin integrity in contrast to other lubricants used by couples."