Clinically Shown to Be Fertility-Friendly

Read about Pre-Seed™ Fertility-Friendly Lubricant's efficacy and how the first lubricant to be sperm friendly as confirmed by independent studies has helped patients conceive.


The Effects of Vaginal Lubricants on Sperm Function

The Journal of Assisted Reproduction and Genetics. January 2014
Alex Mowat, Cora Newton, Clare Boothroyd, Kristy Demmers & Steven Fleming


In Vitro Effects of Coital Lubricants and Synthetic and Natural Oils on Sperm Motility

Fertility and Sterility. February 2014
Ranjit S. Sandhu, B.S., Timothy H. Wong, B.A., Crystal A. Kling, B.S., and Kazim R. Chohan, Ph.D.


Effect of an Isotonic Lubricant on Sperm Collection and Sperm Quality

Fertility and Sterility. 2013; 99, 4
Ashok Agarwal, Ph.D., Helena Malvezzi, M.S., , Rakesh Sharma, Ph.D.


What should it take to describe a substance or product as 'sperm safe'

Human Reproduction Update, Vol. 19, Supplement l pp. il-i48, 2013


Sperm Toxicity of ‘Nonspermicidal’ Lubricant and Ultrasound Gels Used in Reproductive Medicine.

Fertility & Sterility. 2011;95:835-836


Quantitative Perceptual Differences Among Over-the-Counter Vaginal Products

Using a Standardized Methodology. Contraception. 2011;84:184-193


Effect of Vaginal Lubricants on Sperm Motility and Chromatin Integrity:

A Prospective Comparative Study.
Fertility & Sterility. 2008 Feb;89:375-379


Prevalence of Vaginal Dryness in Trying-to-Conceive Couples.

Pacific Coast Reproductive Society, April 2003

Medical Reviews & Guidelines

Products for Sexual Lubrication: Understanding and Addressing Options With Your Patients.

Nursing for Women's Health. 2011 Jun/Jul;15:253-257


Optimizing Natural Fertility.

Fertility & Sterility. 2008 Nov;90(Suppl 3):S1-S6


Dyspareunia and Vaginal Dryness after Breast Cancer Treatment

Dyspareunia and Vaginal Dryness after Breast Cancer Treatment

Clinical Textbook Mentions

Cancer and Sexual Health

JP Mulhall © 2011

In this reference book for cancer care providers, Pre-Seed is listed as a water-soluble lubricant that does not decrease sperm motility.

Male Infertility: Problems and Solutions

ES Sabanegh MD © 2011

The chapter on the initial consultation for male infertility states: "In 2008, in vitro studies suggest that a newer commercially available hydroxyethylcellulose-based lubricant, such as Pre-Seed, has minimal deleterious effects on mobility and sperm chromatin integrity.”

A Practical Guide to Basic Laboratory Andrology

L Bjorndahl, D Mortimer, et al. © 2010

In this laboratory guide, the authors state: "If a lubricant must be used then it must not show any toxicity to spermatozoa. Currently, the only suitable commercial product for this particular purpose is Pre’, an external use version of the Pre-Seed vaginal lubricant…"

Love Sex Again: A Gynecologist Finally Fixes the Medical Problems That Are Sabotaging Your Sex Life Hardcover

by Lauren Streicher (Author)

Dr. Streicher, a leading women's sexual health expert, recommends Pre-Seed Fertility Friendly Lubricant for women who are trying to conceive. Women who are having timed intercourse to coincide with ovulation may find that some extra lubrication can make sex more enjoyable. Pre-Seed is recommended by Dr. Streicher because it does not affect sperm viability and is less irritating than most leading lubricants.

Fertility for Beginners: The Fertility Diet and Health Plan to Start Maximizing Your Fertility Paperback

by Shasta Press (Author)

Fertility for Beginners is a guide to healthy and effective methods for increasing your fertility naturally, and getting one step closer to becoming pregnant. One of the questions this book answers is whether lubricants can be used during sex when you are trying to get pregnant. Pre-Seed Fertility-Friendly lubricant is mentioned because it mimics the body’s natural lubrication and provides an optimal, pH balanced environment for sperm. However, most other lubricants, from vegetable oil to petroleum jelly to saliva, can kill sperm.

Fertility Preservation in Male Cancer Patients

by Doctor John P. Mulhall, Linda D. Applegarth, Doctor Robert D. Oates and Doctor Peter N. Schlegel (Apr 8, 2013)

Written by international authorities in the field of fertility preservation, this comprehensive book reviews the impact of cancers and cancer treatment on male fertility, the available fertility preservation strategies and post-treatment management. Pre-Seed Fertility Friendly lubricant is recommended as a coital lubricant because studies show it had no apparent detrimental effects on semen motility or chromatin integrity.

Hot and Fast: Sexy, Spontaneous Quickies for Passionate Orgasms Paperback

by Megan Andelloux (Author)

This book features everything you need to know for fast, fun, sexy encounters. It also includes a section on sex for those who are trying to get pregnant. While recognizing that scheduled intercourse can be tedious, the author offers a helpful solution to make sex more fun and still be safe for use when trying to conceive – Pre-Seed Fertility Friendly lubricant.

An Introduction to Male Reproductive Medicine

C Niederberger MD © 2011

In this medical text written by well-renowned experts, Dr. Craig Niederberger writes: "Virtually all lubricants impair sperm, including saliva. However, some couples need lubricants for intercourse. A recent survey of the effects of various lubricants on sperm motility and DNA quality suggested that Pre-Seed appears to have the least negative effect on sperm.”

Hacker & Moore’s Essentials of Obstetrics and Gynecology

N Hacker MD, J Gambone DO, MPH, C Hobel MD © 2010

In this classic textbook for medical students, the authors write: "Lubricants may be toxic to sperm. A nontoxic lubricant, Preseed, has been developed for infertile couples."

Maternity and Pediatric Nursing

S Scott Ricci & T Kyle © 2009

In this book for nursing professionals, Pre-Seed is listed as a water-soluble lubricant that can reduce discomfort during intercourse.

Men's Sexual Health and Fertility: A Clinician's Guide [Hardcover]

by John P. Mulhall, Wayland Hsiao

Men’s Sexual Health and Fertility focuses on the interplay and interconnections between male sexual dysfunction and male factor infertility. In this book, the authors cite research that has shown that many lubricants have demonstrated varied effects on sperm including reduced viability, altered morphology, DNA damage and impaired motility. However, the authors also mention that Pre-Seed Fertility Friendly lubricant was studied and was shown to have minimal impact on semen parameters as compared to other lubricants like Astroglide and Pre-Seed.

Surgical and Medical Management of Male Infertility[Hardcover]

by Marc Goldstein MD, Doctor Peter N. Schlegel MD

With contributions from world-renowned experts, this comprehensive overview of male infertility covers anatomy, evaluation, treatment and prevention. Research shows that most coital lubricants can significantly impair sperm motility and adversely affect fertility. However, in a comparative study, Pre-Seed Fertility-Friendly lubricant was shown to not cause a significant decrease in sperm motility or chromatin integrity.

Managing The Stress Of Infertility: How To Balance Your Emotions, Get The Support You Need, And Deal With Painful Social Situations When You're Trying To Become Pregnant Paperback

by Carol Fulwiler Jones MA (Author)

In this step-by-step infertility guide, Pre-Seed Fertility Friendly lubricant is recommended to help with painful intercourse. Pre-Seed is recommended as safe to use during infertility.